Kuyesa kwachipatala kwayambika ku Democratic Republic of the Congo (DRC) kuti awone momwe mankhwala oletsa tizilombo toyambitsa matenda a tecovirimat (omwe amadziwikanso kuti TPOXX) mwa akulu ndi ana omwe ali ndi nyani.Chiyesocho chiwunika chitetezo cha mankhwalawa komanso kuthekera kwake kuchepetsa zizindikiro za nyani ndikupewa zotsatira zoyipa, kuphatikiza imfa.Pansi pa mgwirizano wa maboma a PALM, National Institute of Allergy and Infectious Diseases (NIAID), gawo la National Institutes of Health, ndi National Institute for Biomedical Research (INRB) ya Democratic Republic of the Congo ndi omwe akutsogolera kafukufukuyu..Mabungwe ogwirizana akuphatikizapo US Centers for Disease Control and Prevention (CDC), Antwerp Institute of Tropical Medicine, International Alliance of Health Organizations (ALIMA), ndi World Health Organization (WHO).
Wopangidwa ndi kampani yopanga mankhwala SIGA Technologies, Inc. (New York), TPOXX ndi FDA yovomerezedwa ndi nthomba.Mankhwalawa amaletsa kufalikira kwa kachilomboka m'thupi, kuteteza kutulutsidwa kwa tinthu tating'onoting'ono ta ma virus m'maselo a thupi.Mankhwalawa amalimbana ndi puloteni yomwe imapezeka mu kachirombo ka nthomba komanso kachirombo ka nyani.
"Monkeypox imayambitsa kulemedwa kwakukulu kwa matenda ndi imfa pakati pa ana ndi akuluakulu ku Democratic Republic of the Congo, ndipo njira zowonjezera zothandizira zikufunika mwamsanga," adatero Mtsogoleri wa NIAID Anthony S. Fauci, MD.Kuchita bwino kwa chithandizo cha nyanipox.Ndikufuna kuthokoza asayansi omwe timagwira nawo ntchito ku DRC ndi a Kongo chifukwa chopitiliza kugwirira ntchito limodzi popititsa patsogolo kafukufuku wofunikira wachipatalawu.”
Kachilombo ka Monkeypox kamayambitsa matenda komanso kufalikira kwapang'onopang'ono kuyambira m'ma 1970, makamaka m'madera amvula ku Central ndi West Africa.Kuyambira Meyi 2022, miliri yambiri ya nyani yapitilira m'malo omwe matendawa sanachuluke, kuphatikiza ku Europe ndi United States, pomwe milandu yambiri imachitika mwa amuna omwe amagonana ndi amuna.Mliriwu udapangitsa bungwe la World Health Organisation ndi US department of Health and Human Services posachedwapa kulengeza zavuto lazaumoyo.Kuyambira pa Januware 1, 2022 mpaka Okutobala 5, 2022, WHO idanenanso kuti anthu 68,900 adatsimikizika ndi 25 afa m'maiko 106, madera ndi madera.
Malinga ndi World Health Organisation, milandu yomwe yadziwika kuti ndi gawo la mliri womwe ukupitilira padziko lonse lapansi makamaka chifukwa cha kachilombo ka Clade IIb monkeypox.Clade I akuti amayambitsa matenda oopsa komanso kufa kwachulukidwe, makamaka kwa ana, kuposa clade IIa ndi clade IIb, ndipo ndizomwe zimayambitsa matenda ku Democratic Republic of the Congo.Kuyambira pa Januware 1, 2022 mpaka Seputembara 21, 2022, bungwe la African Centers for Disease Control and Prevention (Africa CDC) linanena milandu 3,326 ya nyani (165 yatsimikizika; 3,161 akuwakayikira) ndi 120 omwe afa.
Anthu amatha kutenga nyani pokhudzana ndi nyama zomwe zili ndi kachilombo monga makoswe, anyani omwe si anthu, kapena anthu.Kachilombo kameneka kamafalikira pakati pa anthu pokhudzana ndi zotupa zapakhungu, madzi am'thupi ndi madontho opangidwa ndi mpweya, kuphatikizapo kukhudzana ndi kugonana, komanso kukhudzana ndi zovala zowonongeka kapena zogona.Monkeypox imatha kuyambitsa zizindikiro za chimfine komanso zotupa zopweteka pakhungu.Mavuto angaphatikizepo kutaya madzi m'thupi, matenda a bakiteriya, chibayo, kutupa kwa ubongo, sepsis, matenda a maso, ndi imfa.
Mlanduwu ukhudza akulu okwana 450 ndi ana omwe ali ndi matenda a monkeypox omwe amalemera ma kilogalamu atatu.Amayi apakati nawonso ali oyenera.Anthu odzipereka adzapatsidwa mwachisawawa kuti amwe makapisozi a tecovirimat kapena placebo pakamwa kawiri tsiku lililonse kwa masiku 14 pa mlingo womwe umatengera kulemera kwa wophunzirayo.Kafukufukuyu anali wakhungu kawiri, kotero otenga nawo mbali ndi ofufuza sanadziwe yemwe angalandire tecovirimat kapena placebo.
Onse omwe atenga nawo mbali adzakhala m'chipatala kwa masiku osachepera 14 komwe adzalandira chithandizo chothandizira.Madokotala ofufuza nthawi zonse aziyang'anira momwe odwala alili panthawi yonse ya kafukufukuyu ndipo adzapempha ophunzira kuti apereke zitsanzo za magazi, zotupa zapakhosi, ndi zotupa zapakhungu kuti awonedwe la labotale.Cholinga chachikulu cha phunziroli chinali kufananiza nthawi yayitali yochiritsa zilonda zapakhungu kwa odwala omwe amathandizidwa ndi tecovirimat motsutsana ndi placebo.Ofufuzawa asonkhanitsanso zambiri pazifukwa zingapo zachiwiri, kuphatikiza kufananiza momwe otenga nawo gawo adayezetsa mwachangu kuti alibe kachilombo ka monkeypox m'magazi awo, kuopsa konse komanso nthawi ya matendawa, komanso kufa pakati pamagulu.
Ophunzirawo adatulutsidwa m'chipatala pambuyo poti zilonda zonse zidasweka kapena kung'ambika ndipo adayezetsa kuti alibe kachilombo ka nyani m'magazi mwawo kwa masiku awiri otsatizana.Adzawonedwa kwa masiku osachepera 28 ndipo adzafunsidwa kuti abwerere m'masiku 58 kuti akayendere mwakufuna kwawo kukayezetsa zachipatala ndi zasayansi.Komiti yodziyimira payokha yowunikira deta ndi chitetezo idzayang'anira chitetezo cha omwe akutenga nawo mbali mu nthawi yonse ya kafukufukuyu.
Phunziroli linatsogoleredwa ndi wofufuza wamkulu Jean-Jacques Muyembe-Tamfum, Mtsogoleri Wamkulu wa INRB ndi Pulofesa wa Microbiology, Faculty of Medicine, University of Kinshasa, Gombe, Kinshasa;Placid Mbala, MD, PALM Program Manager, Head of the INRB Epidemiology Division and the Pathogen Genomics Laboratory.
“Ndili wokondwa kuti nyani salinso matenda onyalanyazidwa ndipo posachedwapa, chifukwa cha kafukufukuyu, tisonyeza kuti pali mankhwala othandiza pa matendawa,” adatero Dr. Muyembe-Tamfum.
Kuti mudziwe zambiri, pitani ku Clinicaltrials.gov ndikusaka ID NCT05559099.Ndondomeko yoyesera idzadalira mlingo wolembetsa.Mlandu wa TPOXX wothandizidwa ndi NIAID ukuchitika ku United States.Kuti mumve zambiri za mayeso aku US, pitani patsamba la AIDS Clinical Trials Group (ACTG) ndikufufuza TPOXX kapena phunzirani A5418.
PALM ndi chidule cha "Pamoja Tulinde Maisha", mawu a Chiswahili omwe amatanthauza "kupulumutsa miyoyo pamodzi".NIAID idakhazikitsa mgwirizano wofufuza zachipatala wa PALM ndi Unduna wa Zaumoyo ku DRC poyankha mliri wa Ebola wa 2018 kummawa kwa DRC.Mgwirizanowu ukupitilira ngati pulogalamu yofufuza zachipatala yamitundu yosiyanasiyana yomwe ili ndi NIAID, DRC Health department, INRB ndi anzawo a INRB.Kafukufuku woyamba wa PALM anali kuyesa kosasinthika kwamankhwala angapo a matenda a Ebola omwe adathandizira kuvomerezedwa ndi NIAID-developed mAb114 (Ebanga) ndi REGN-EB3 (Inmazeb, yopangidwa ndi Regeneron).
NIAID imachita ndi kuthandizira kafukufuku ku NIH, United States, ndi padziko lonse lapansi kuti amvetsetse zomwe zimayambitsa matenda opatsirana ndi chitetezo chamthupi ndikupanga njira zabwino zopewera, kuzindikira, ndi kuchiza matendawa.Zofalitsa, zolemba zamakalata, ndi zinthu zina zokhudzana ndi NIAID zikupezeka patsamba la NIAID.
Za National Institutes of Health (NIH): National Institutes of Health (NIH) ndi bungwe lofufuza zamankhwala ku United States lomwe lili ndi masukulu ndi malo 27 ndipo ndi gawo la US Department of Health and Human Services.NIH ndiye bungwe lalikulu la federal lomwe limachita ndikuthandizira kafukufuku wazachipatala woyambira, wazachipatala, komanso womasulira, kufufuza zomwe zimayambitsa, machiritso, ndi chithandizo cha matenda wamba komanso osowa.Kuti mumve zambiri za NIH ndi mapulogalamu ake, pitani www.nih.gov.
Nthawi yotumiza: Oct-14-2022
